Clotamin, a Multivitamin without Vitamin K

Publication Date: 
Mon, 09/03/2012
By: Alere Staff

The Clotamin® multivitamin, introduced in 2008, is marketed for patients taking anticoagulants such as warfarin (brand name Coumadin® medication). It is offered as a complete multivitamin without vitamin K. Clotamin® multivitamin is manufactured in a good manufacturing practice (GMP) lab, under conditions that have been recognized worldwide for high quality control and superior manufacturing standards.1

Clotamin was founded by warfarin patient Justin Barch. He developed this product with the goal of offering a multivitamin without vitamin K. Clotamin has thousands of customers across the country and has been sold in over 15 countries.

Formula for Clotamin® multivitamin



% of Daily Vitamin

 Vitamin A

3000 IU


 Vitamin C (ascorbic acid)

60 mg


 Vitamin D-3 (cholecalciferol)

200 IU


 Vitamin E (di-alpha tocopheryl acetate)

15 IU


 Thiamine HCL (vitamin B1)

3 mg


 Riboflavin (vitamin B2)

3.4 mg



20 mg


 Vitamin B6 (pyridoxine HCI)

4 mg


 Folic Acid

400 mcg


 Vitamin B-12

24 mcg



300 mcg


 Pantothenic Acid

10 mg


 Calcium (carbonate)

120 mg


 Magnesium (oxide)

50 mg


 Zinc (oxide)

15 mg


 Selenium (selenomethionine)

105 mcg


 Copper (gluconate)

2 mg


 Manganese (sulfate)

2 mg


 Chromium (picolynate)

120 mcg


 Potasium (aspartate)

100 mg



600 mcg

 Daily Value
not Established

* International Units (IU), Micrograms (mcg), Milligram mg

The makers of the Clotamin® multivitamin claim that it can be taken with medications like warfarin without affecting International Normalized Ratio (INR) values.1 This claim has not been evaluated by the FDA (Food and Drug Administration), and there are no clinical trials to support this statement.

According to the warfarin package insert, Vitamins C and E are known to influence INR test results in patients taking warfarin.2 The Clotamin® multivitamin contains 100% of recommended daily allowance for vitamin C and 50% of vitamin E. Barch was asked if this was taken into consideration.

“We consulted with a [pharmacist] as well as leading hematologists when developing the formulation for Clotamin® [multivitamin]. We gave special attention to the amount of vitamin C and E in Clotamin. There are reports3 that suggest taking more than 500 mg of vitamin C can have the effect of lowering a patient’s INR. We have an amount well below that in Clotamin (60 mg) and given the fact that vitamin C is water soluble you lose much of that during urination. Vitamin E is found in many leafy green vegetables such as spinach and broccoli; we have found many of our customers have limited their consumption of these foods because of their high concentration of vitamin K. For that reason we thought it was important to have at least 15 iu of vitamin E in Clotamin® [multivitamin]. Reports have shown that taking over 400 iu4 of vitamin E may increase a patient’s INR. We recommend that all of our customers speak to their physicians before taking Clotamin.”

Barch stated his company is developing additional products for patients taking warfarin, including a 50 mcg vitamin K pill to help stabilize INR’s as well as a 500 mg vitamin K pill to act as a reversal agent in the hospital setting for patients that have excessively high INR’s.

The Clotamin® multivitamin is available from the manufacturer ( as well at leading retailers across the country. Patients are encouraged to speak with their doctor before starting or stopping any new products,2 including Clotamin.

  1. Clotamin – A multivitamin without vitamin K. Retrieved January 26, 2009, from Clotamin Web site:
  2. Bristol-Myers Squibb Company. Medication Guide for Coumadin Tablets and Coumadin for Injection (Package Insert). Princeton, NJ. Bristol-Myers Squibb Company. 2009.
  3. Harris, J.E. Interaction of dietary factors with oral anticoagulants: review and applications. Journal of the American Dietetic Association, 95, 580-4. 1995.
  4. Corrigan, J., and Marcus F.L. Coagulopathy associated with vitamin E ingestion. JAMA, 230 (9), 1300-1. 1974.