Cipro Prolonged Release Tablets and Warfarin

Ciprofloxacin Prolonged-Release Tablets cleared of having interactions with warfarin seems to be an exception to the rule.

A study published in the Journal of Clinical Pharmacology (Oct. 2007) entitled, "Ciprofloxacin Prolonged-Release Tablets Do Not Affect Warfarin Pharmacokinetics and Pharmacodynamics", cleared (somewhat) from interacting with warfarin. "There were no significant differences in pharmacokinetic or pharmacodynamic parameters among treatments. These results show that warfarin pharmacokinetics and pharmacodynamics are not altered with concomitant administration of ciprofloxacin PR."¹

A small study of 18 healthy male volunteers between the age of 18-55 were evaluated in a single dose (7.5mg warfarin dose, 500mg ciprofloxacin PR dose). This study tested the interaction between Ciprofloxacin and warfarin, including the absorbtion, distribution and metabolism.

As with all medications, please dicuss taking Ciprofloxacin with your doctor. More frequent monitoring of your INR may be neccessary to determine if warfarin interactions occur.

1. Berner B, et al. Ciprofloxacin Prolonged-Release Tablets Do Not Affect Warfarin Pharmacokinetics and Pharmacodynamics. J Clin Parmacol. October 2007 vol 47 no. 10 1320-1326.