A Protonix® Prescription and Warfarin

Publication Date: 
Mon, 09/12/2016
By: Alere Staff

If you experience chest pain, nausea, sweating and a general feeling of illness, you may first believe that you are experiencing a heart attack. Many patients, however, have found that they are instead suffering from severe heart burn.1 While this may be a better prognosis, heartburn also needs management to ensure your health. 

Proton Pump Inhibitors 

When patients experience constant heartburn, acid reflux and other stomach acid-related conditions, their physicians may prescribe them a proton pump inhibitor. A common proton pump inhibitor prescribed is the Protonix® medication, also known as pantoprazole. A Protonix® prescription works by reducing the amount of acid that is produced in the stomach.1 A proton pump inhibitor like the Protonix® medication is not intended to provide immediate heartburn relief. Instead, it is intended to work over a period of time, healing damage to the esophagus and other areas the stomach acid might have affected.1 

The most common ways that the Protonix®  medication is taken is by tablet or through a delayed-release oral suspension. Some of the side effects that patients can experience are headache, nausea, stomach pain, vomiting and dizziness. An allergic reaction to medication can include a rash, face swelling, throat tightness or difficulty breathing.2 It is important to let your prescribing physician know if you experience any of the following conditions:2

  • Seizures
  • Dizziness
  • Jitteriness
  • Jerking movements or tremors
  • Abnormal or fast heartbeat
  • Muscle weakness
  • Spasms of the hands of feet
  • Cramps or muscle aches
  • Spasm of the voice box 

Take the Protonix® medication exactly as your doctor prescribes and for the recommended length of time. In some cases, patients who take multiple doses of proton pump inhibitor medications for extended periods of time have experienced an increased risk of fractures in their hip, wrist or spine.2 

A Protonix® Prescription and Warfarin 

If you are a patient who has been on an anticoagulation medication like warfarin, you might already be aware of the possible interactions with different medications associated with heart burn and stomach upset. Patients who are given a Protonix® prescription may be asked to test their INR more frequently. Anticoagulation patients who take the Protonix® medication have shown an increased risk of bleeding in rare cases.2 You should call your doctor if you experience signs of bleeding such as unusual bleeding or bruising, swelling, vomiting, blood in your urine or stools or headaches.2 Proton pump inhibitors like the Protonix® medication can help heal your digestive system, but, as with any new prescription or condition, it is important to keep your doctor informed and aware of your health. 


  1. Drugs.com. Protonix. 2016. Retrieved from the website: https://www.drugs.com/drug-interactions/protonix-with-warfarin-1790-1152-2311-0.html
  2. December 2014. Medication Guide, website download: http://labeling.pfizer.com/ShowLabeling.aspx?id=135&section=MedGuide.

Protonix® is a registered trademark of the Pfizer group of companies. Under license from Takeda, D78467 Konstanz, Germany. Alere is not affiliated or associated with the Pfizer group of companies or Takeda GmbH or the Protonix® trademark.