Estroven® supplement and Warfarin

Publication Date: 
Tue, 11/08/2011
By: Alere Staff

Symptomatic relief from menopause often comes in the form of over the counter medications. A recent question came to PTINR.com regarding the product Estroven.

Estroven® supplement is registered as a dietary supplement by the U.S. Food and Drug Administration (FDA). According to the FDA, a dietary supplement is "a product taken by mouth that contains a 'dietary ingredient' intended to supplement the diet. The 'dietary ingredients' in these products may include: vitamins, minerals, herbs or other botanicals."1 Dietary supplements are not regulated like other drug products, but manufacturers are responsible for ensuring that product label information is truthful and not misleading.

Be cautious of assuming a natural medicine or herbal supplement is safe. Many dietary supplements have the potential to cause a serious drug interaction with warfarin. According to the Estroven® supplement website, it contains “soy isoflavones, standardized black cohosh, calcium and boron, and natural vitamins E, B-6, B-12, and folic acid.” Both soy and black cohosh have been know to interact with warfarin's effectiveness.2,3  

As always, discuss any diet or dietary supplement changes with your doctor.

  1. U.S. Food and Drug Administration. Overview of Dietary Supplements. 2011.
  2. Ibrahim S, Nutescu E, Shapiro N, West P. Warfarin and its interactions with foods, herbs and other dietary supplements. May 2006, Vol. 5, No. 3 , Pages 433-451.
  3. Kronenberg F, Fugh-Berman A. Complementary and Alternative Medicine for Menopausal Symptoms: A Review of Randomized, Controlled Trials. November 19, 2002. vol. 137 no. 10 805-813.