PTINR.com
Aged Garlic Extract & Warfarin
Saturday, April 1, 2006
PTINR.com Staff
Herbal supplements at large remain a challenge - garlic looks to be safe
Garlic has been promoted for cardiovascular health by spokespersons such as Larry King. Recently the American Society for Nutrition’s March 2006 issue evaluated the influence of garlic on patient’s INR test results.
Forty-eight patients were evaluated on the affect of aged garlic extract (AGE). In the study patients received doses of 5mL twice a day for twelve weeks. Hemorrhagic and thromboembolic events were monitored.
The authors concluded, “There was no evidence of increased hemorrhage in either the placebo or the AGE group. Adverse events included headache, fatigue, colds, and dizziness. However, no significant difference was found in the incidence of these minor adverse events between the groups. Thus, the adverse events are unlikely to be attributable to AGE. The results suggest that AGE is relatively safe and poses no serious hemorrhagic risk for closely monitored patients on warfarin oral anticoagulation therapy. Although the risk-benefit ratio of AGE use needs to be considered carefully when warfarin (Coumadin ®) therapy is necessary, its positive effects may be beneficial to people with a high-risk background or who are taking cardiovascular medications.”American Society for Nutrition, March 2006
Changes in an INR results caused by herbal supplements are seen more quickly with weekly testing. To prevent patients from self-managing themselves without direction - professionals are encouraged to use the QAS Home Testing Protocol found on the professional home page of www.ptirn.com. The protocol will allow professionals to establish parameters and guidance to correct slightly out of range results.